{"id":82799,"date":"2025-08-21T20:13:29","date_gmt":"2025-08-21T20:13:29","guid":{"rendered":"https:\/\/www.merckconnect.ca\/en\/?post_type=mhh-sticky-footer&#038;p=82799"},"modified":"2026-01-23T18:04:56","modified_gmt":"2026-01-23T18:04:56","slug":"82799","status":"publish","type":"mhh-sticky-footer","link":"https:\/\/www.merckconnect.ca\/en\/mhh-sticky-footer\/82799\/","title":{"rendered":"Winrevair"},"content":{"rendered":"<div class=\"mhh-sticky-footer-panel mhh-sticky-footer-panel--3aee28d4b07819e6173b4175c7e95ed5\">\n    <button class=\"mhh-sticky-footer-panel__expand-button\" \n            data-event-name=\"accordion_click\" \n            data-design-module=\"indication\"\n            data-design-category=\"accordion\"\n            data-design-label=\"expand\">\n                    <svg\n            xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n            fill=\"currentColor\"\n            viewBox=\"0 0 16 16\"\n            >\n            <path\n            d=\"M8 4a.5.5 0 0 1 .5.5v3h3a.5.5 0 0 1 0 1h-3v3a.5.5 0 0 1-1 0v-3h-3a.5.5 0 0 1 0-1h3v-3A.5.5 0 0 1 8 4z\"\/>\n            <\/svg>\n                <span>EXPAND<\/span>\n        <\/button>\n    <div class=\"mhh-sticky-footer-inner\">\n    \n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p dir=\"ltr\" lang=\"en-US\" class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size mhh-mcn-v1-paragraph--right  mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--88ebe9b30bf7fd3b517609eaac53f3d6\"><a href=\"https:\/\/www.merck.ca\/en\/wp-content\/uploads\/sites\/20\/2024\/08\/WINREVAIR_PM_E-.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">WINREVAIR\u00ae Product Monograph<\/a><\/p>\n\n\n\n<p dir=\"ltr\" lang=\"en-US\" class=\"has-border-color has-has-red-border-color-border-color has-white-color has-text-color  has-link-color has-object-object-font-size wp-elements-6f21a9b571a2d880b49a99cf4c3944e2 mhh-mcn-v1-paragraph--center  mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--2ec87c467ee513991ba4d190e6790277\" style=\"background-color:#1b365d\"><strong>IMPORTANT SAFETY INFORMATION<\/strong><\/p>\n\n    <\/div>\n<\/div>\n\n\n<div class=\"mhh-sticky-footer-expanded-panel mhh-sticky-footer-expanded-panel--f50bf3832e14000c7dbe72662d79e6cc \" dir=\"ltr\">\n    <div class=\"mhh-sticky-footer-expanded-panel__inner\">\n        <div class=\"mhh-sticky-footer-expanded-panel__close-button-wrapper\">\n            <button class=\"mhh-sticky-footer-expanded-panel__close-button\">\n                        <svg\n                xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n                fill=\"currentColor\"\n                viewBox=\"0 0 16 16\"\n            >\n                <path\n                d=\"M4.646 4.646a.5.5 0 0 1 .708 0L8 7.293l2.646-2.647a.5.5 0 0 1 .708.708L8.707 8l2.647 2.646a.5.5 0 0 1-.708.708L8 8.707l-2.646 2.647a.5.5 0 0 1-.708-.708L7.293 8 4.646 5.354a.5.5 0 0 1 0-.708z\"\/>\n            <\/svg>\n                                    <\/button>\n        <\/div>\n        <div class=\"mhh-sticky-footer-expanded-panel__body\">\n            \n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--7400c344be137b490c48b58fcd4240ef mhh-mcn-v1-columns mhh-mcn-columns--gutter-custom\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--fe5b23e94250eb817f867f8e0405b969 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<p dir=\"ltr\" lang=\"en-US\" class=\"has-border-color has-has-red-border-color-border-color has-white-color has-text-color  has-link-color has-object-object-font-size wp-elements-aba8afd0805f5c2cdfbb5fbb8a912571 mhh-mcn-v1-paragraph--center  mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--6e0e31ef2fc0cd6e572d6b23fdd18449\" style=\"background-color:#1b365d\"><strong>IMPORTANT SAFETY INFORMATION<\/strong><\/p>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--1d65c4b304cdbaca84cfa5aaf42c0cf6\">WINREVAIR\u00ae is indicated, in combination with standard PAH therapy, for the treatment of adults with <span class=\"no-text-breaking\">WHO Group 1<\/span> PAH <span class=\"no-text-breaking\">and FC II or III.<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color has-link-color has-object-object-font-size wp-elements-dcc319d7f08cb3bd4bb5d5f2396eea37  mhh-mcn-v1-heading mhh-mcn-v1-heading--4c135825b0b734c9792363b06a2f239a\" style=\"color:#1b365d\"><strong>Important safety information<sup>1<\/sup><\/strong><\/h5>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--39cbaad30e928f6f289ea2cbe7209177\"><strong><span style=\"text-decoration: underline\">Clinical use<\/span>:<\/strong><\/p>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--9f6981ab5a3c05a4e9b7f11d9ec0d2fb\">The safety and efficacy of WINREVAIR\u00ae in pediatric patients has not been established and therefore it is not indicated for pediatric use.<\/p>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--42b1bab62f013a4951e5fcf0ae0b3dfc\">Clinical studies of WINREVAIR\u00ae did not include sufficient numbers of patients <span class=\"no-text-breaking\">aged 75<\/span> and older to determine whether they respond differently from younger patients.<\/p>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--8e02576d2ce235cc626eac3dfa072200\"><strong><span style=\"text-decoration: underline\">Relevant warnings and precautions<\/span><\/strong>:<\/p>\n\n\n\n<ul class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--813fe3e89abf3579903ff5138d79599f mhh-mcn-list mhh-mcn-v2-clist--unordered mhh-mcn-v2-clist--unordered-dot\" dir=\"ltr\" lang=\"en-US\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Hematologic adverse reactions    \n\n<ul class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--3e259219b2dab2884a09fdd480ca806d mhh-mcn-list mhh-mcn-v2-clist--unordered mhh-mcn-v2-clist--unordered-line\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Increased hemoglobin; monitor before each dose for at least the first <span class=\"no-text-breaking\">5 doses,<\/span> or longer if values are unstable, and periodically thereafter to determine if dose adjustments are required    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Severe thrombocytopenia; WINREVAIR\u00ae should not be initiated in patients with platelet <span class=\"no-text-breaking\">count &lt;50,000\/mm<sup>3<\/sup><\/span> (&lt;50.0 x 10<sup>9<\/sup>\/L). Monitor platelet count before each dose for the first <span class=\"no-text-breaking\">5 doses,<\/span> or longer if values are unstable, and periodically thereafter to determine whether dose adjustments are required    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Serious bleeding, advise patients about signs and symptoms of blood loss    <\/li>\n\n<\/ul>\n\n<\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Teratogenic risk, embryo-fetal toxicity    <\/li>\n\n<\/ul>\n\n\n\n<ul class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--5a98549d992228f305ff33768d615215 mhh-mcn-list mhh-mcn-v2-clist--unordered mhh-mcn-v2-clist--unordered-dot\" dir=\"ltr\" lang=\"en-US\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Pregnancy testing is recommended for females of reproductive potential before starting treatment    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Females of reproductive potential should use effective contraception during treatment with WINREVAIR\u00ae and for at least <span class=\"no-text-breaking\">4 months<\/span> after the last dose if treatment is discontinued    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Advise male and female patients on the potential effects on fertility    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Advise females not to breastfeed during treatment and for <span class=\"no-text-breaking\">4 months<\/span> after the final dose if treatment is discontinued    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Pediatrics    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Geriatrics    <\/li>\n\n<\/ul>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--28a0c95cac86f7dc57effff74d06edd5\"><strong><span style=\"text-decoration: underline\">For more information<\/span>:<\/strong><\/p>\n\n\n\n<p class=\"has-link-color has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-object-object-font-size  has-link-color mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--131ea5df90aaf5f82f93298845528879\">Consult the WINREVAIR\u00ae <a href=\"https:\/\/www.merck.ca\/en\/wp-content\/uploads\/sites\/20\/2024\/08\/WINREVAIR_PM_E-.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Product Monograph<\/a> for important information regarding adverse reactions, drug interactions, and dosing information which have not been discussed in this piece. The Product Monograph is also available by calling us at <span class=\"no-text-breaking\">1-800-567-2594<\/span> or by email at <span class=\"no-text-breaking\">medinfocanada@merck.com.<\/span><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n<div class=\"mhh-sticky-footer-safety-content\">\n    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